Mon 29 Mar 2010
The role of toxins in Autism
Posted by mdnutrition under Autism, lead, mercury, toxins
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Below is an abstract from Dr. Landigan, the head at Mt Sinai Medical Center in NYC talking about the role of toxins in the development of Autism. His credentials are impeccable. Getting rid of toxins in our bodies, from amalgam fillings containing mercury, to fluoride in our water, is critical.
Current Opinion in Pediatrics:
April 2010 – Volume 22 – Issue 2 – p 219–225
doi: 10.1097/MOP.0b013e328336eb9a
Therapeutics and toxicology: Edited by Robert O. Wright
What causes autism? Exploring the environmental contribution
Landrigan, Philip J
Abstract
Purpose of review: Autism is a biologically based disorder of brain development. Genetic factors – mutations, deletions, and copy number variants – are clearly implicated in causation of autism. However, they account for only a small fraction of cases, and do not easily explain key clinical and epidemiological features. This suggests that early environmental exposures also contribute. This review explores this hypothesis.
Recent findings: Indirect evidence for an environmental contribution to autism comes from studies demonstrating the sensitivity of the developing brain to external exposures such as lead, ethyl alcohol and methyl mercury. But the most powerful proof-of-concept evidence derives from studies specifically linking autism to exposures in early pregnancy – thalidomide, misoprostol, and valproic acid; maternal rubella infection; and the organophosphate insecticide, chlorpyrifos. There is no credible evidence that vaccines cause autism.
Summary: Expanded research is needed into environmental causation of autism. Children today are surrounded by thousands of synthetic chemicals. Two hundred of them are neurotoxic in adult humans, and 1000 more in laboratory models. Yet fewer than 20% of high-volume chemicals have been tested for neurodevelopmental toxicity. I propose a targeted discovery strategy focused on suspect chemicals, which combines expanded toxicological screening, neurobiological research and prospective epidemiological studies.